The 16th Annual Great Plains Infectious Disease Meeting
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چکیده
“Vaccination Studies with Live Attenuated Burkholderia Strains” Burkholderia pseudomallei, the etiologic agent of melioidosis, is responsible for a variety of infections in humans and animals in tropical and subtropical regions. It is facultative intracellular pathogen that has been designated as a Tier 1 select agent because it has the potential to pose a severe threat to public health and safety. No protective antigens have been identified and there are no licensed vaccines. Live attenuated B. pseudomallei vaccines have provided significant protection in animal models of infection, but sterilizing immunity is rarely achieved. In order to improve protection and generate sterilizing immunity, we employed a rational design strategy for the development of live vaccine candidates. Auxotrophic mutants were screened for attenuation and persistence and the best candidates were further optimized with mutations in genes that enable B. pseudomallei to evade the host innate immune response. By combining the best auxotrophic and host immune evasion gene mutations we have generated live vaccine candidates that have resulted in enhanced protection and immunity in BALB/c mice.
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تاریخ انتشار 2017